Blue Light Empirical Shine Study: a pilot case series

31 October 2023

Title: Blue Light Empirical Shine Study (BLESS) trial: a pilot case series

Authors: Harikrishna KR Nair, Mohd Afzanizam Abdul Khalib, Rosy Abdul Rashid R, Ng Ming Lee

Year: 2023

Publication: Wounds APAC 2023, Vol 6 Issue 3, pag. 39-47



  • In this case series, nine patients with lower limbs non-healing wounds of different aetiologies were treated with Blue Light Photobiomodulation therapy (EmoLED) at the Specialist Clinic Ambulatory Care Centre, Hospital Kuala Lumpur, Malaysia (SCACC HKL).
  • Non healing wound is defined as a wound that has not healed by 40–50% after four weeks of good standard of care. The patients enrolled were not responding to standard care for an average of 62 days before Blue Light therapy.
  • The patient’s ages ranged from 45 to 83 years. Of the nine patients, seven had diabetes mellitus, six of which also had vascular diseases.
  • The patients had a diagnosis of: diabetic foot ulcer (5), venous ulcer (1), traumatic wound (1), surgical dehiscence (1) and stump dehiscence (1).
  • All patients underwent standard wound hygiene procedures, including thorough cleansing of the wound with distilled water and, if necessary, debridement and reshaping, before receiving EmoLED treatment.
  • In patients with diabetic foot ulcers (DFUs) and stump dehiscence (diabetic patient) a 120-second weekly treatment was administered to the affected area,  while the other wound types received a 60-second treatment per area.
  • Following each treatment, wounds were managed according to standard care protocols using modern dressing techniques. DFU cases involved offloading, while the venous ulcer received compression therapy.
  • All the patients registered wound closure and the time to achieve complete wound healing was 109 days from the beginning of EmoLED treatment.
  • In this case series, it has been shown that despite having different underlying causes, all nine patients responded positively to Blue Light therapy. This suggests that all wounds shares a common pathophysiological pathway, which results in similar responses to Blue Light and ultimately leads to the same outcome: complete wound healing.
  • To improve the validity of the result, the Authors intend to undertake a more extensive study.