EmoLED - Blue Light

Blue Light

Blue Light for wound healing

The study of the effects of Blue LED Light in the treatment of skin lesions is carried out by Emoled in collaboration with some of the most important Italian research institutes in the field of photonics and clinical research. The range of pathologies studied is wide: chronic wounds (venous, pressure and inflammatory ulcers), diabetic foot, burns and dermatological disorders such as atopic dermatitis. Thanks to this activity, it has been found that Blue Light is able to stimulate the physiological healing process of a wound which, due to a pathology, infection or metabolic deficiencies, may have stopped in the inflammatory phase, becoming chronic.

The energy of light is absorbed by enzymes of the electron transport chain and by flavoproteins present in the tissue cells, directly, without the use of mediators (chemical additives or drugs) and it is used by the skin tissue to promote chemical reactions or produce conformational changes in some biomolecules: cell activity is thus increased or reduced - “modulated” - where this is pathologically altered.

It is Photobiomodulation with Blue Light: this is how this promising photonic therapy has been defined in the scientific literature for its potential in inducing the healing of chronic wounds that represent a serious medical problem worldwide, destined to grow due to the increasing spread of diabetes and an aging population.

Blue light to inactivate viruses and bacteria

Tests carried out at the Microbiology and Virology laboratory of the University of Siena in collaboration with Emoled, have shown that Blue Light has also a virucidal effect, in particular on known viruses such as Adenovirus, Syncytial Respiratory Virus and SARS-COV-2; cultures containing different concentrations of these viruses were irradiated with blue light at different energy intensities and the effects were observed after 72 hours. It was found that after a 15 minutes exposure to Blue Light with a power density of 120 mW/cm2, a 100% reduction of the SARS-COV-2 virus was obtained: it was thus shown that Blue Light is an effective disinfectant being able to induce, under certain irradiation conditions, the inactivation of pathogenic colonies.

In the scientific literature is known the bactericidal capacity of Blue Light that has demonstrated its direct antimicrobial power against a wide spectrum of bacteria and fungi. Due to its capacity to decontaminate both patient wounds and healthcare environments, recently, the antimicrobial power of Blue Light has attracted growing interest in relation to the increasing problem of antimicrobial resistance (AMR) by numerous bacterial species.

If the mechanism of action of Blue Light on viruses is not known to date - it is thought that it has an impact on the protein capsid, damaging its integrity and thus inactivating the virus - we know that the inactivation of bacteria and fungi through Blue Light occurs following photoexcitation of intracellular porphyrins: the energy transfer causes the production of ROS (reactive oxygen species) which are cytotoxic and lead to cell death if present in high concentrations.

The use of Blue Light as a disinfectant for surfaces and objects could help to limit the use of chemical disinfectants, limiting their harmful effects on things and people. Furthermore, the Blue LED Light is completely safe: unlike the use of ultraviolet rays, it does not cause damage to materials and the skin neither it changes the characteristics of the food; only direct eye exposure should be avoided.

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